All Issues

Issue No. 2

Dr. Gupta's Plastic Surgery
Intelligence Briefing

14 articles · 7 sections

Reconstruction · Sensate flaps

Free Flap Neurotization: Indications, Techniques, and Future Directions

Review of current operative approaches to harvesting sensate free flaps, donor/recipient nerve selection, and outcome considerations—reflecting a broader shift toward functional reconstruction where protective sensibility is treated as a primary endpoint.

Aesthetics · Nasal surgery

Modified Rotation-Advancement Alar Flap Technique for Cosmetic Alar Reduction: Surgical Experience With 80 Asian Cases

Case series (80 patients) describing a less-invasive rotation-advancement alar flap approach intended to improve nostril show, alar flare, and symmetry with acceptable scarring over 3–12 months of follow-up.

Wounds · PRP protocol

Exploration of the Therapeutic Protocols and Underlying Molecular Mechanisms of Autologous Platelet-Rich Plasma in the Treatment of Deep Second-Degree Burns

Randomized protocol comparison suggesting PRP improves healing time/coverage and reduces bacterial culture positivity, with early intervention and leukocyte-poor PRP performing best; higher-frequency dosing raised growth-factor levels but did not improve outcomes.

Chronic wounds · PRP evidence

Meta-analysis of platelet-rich plasma for venous ulcers: Clinical efficacy and complications

Systematic review/meta-analysis (13 studies; 554 patients) finding PRP associated with higher odds of complete venous leg ulcer healing (about 1.5×) and lower recurrence (OR ~0.25), with heterogeneity across protocols and populations.

Postop healing · Autologous biologics

Intraoperative platelet-rich plasma in tonsillectomy: A randomized controlled trial of pain and wound-healing outcomes

RCT (n=200) showing topical autologous PRP reduced postoperative pain over days 1–10 and improved early wound healing, with higher complete mucosal healing by day 14 (78% vs 59%).

ADM · Fish-skin matrix

Development and evaluation of a fish skin-derived acellular dermal matrix for diabetic wound healing: In vitro and in vivo assessment

Preclinical diabetic wound work demonstrating cytocompatibility and faster closure versus a commercial comparator, with complete closure by day 21 reported in the fish-skin ADM group.

Smart dressing · ADM composite

An In Situ Embedded B-MOF Sponge With Shape-Memory for All-in-One Diabetic Wound Therapy

Shape-memory pullulan/ADM composite incorporating ZIF-8 MOFs + salvianolic acid B with exudate-triggered shape recovery and pH-responsive release; in a diabetic rat model, authors report ~98.5% healing by day 14 with macrophage repolarization and pro-angiogenic signaling.

Regeneration · 3D printing

The Role of 3D Printing in Regenerative Medicine: A Game-Changer in Tissue Engineering

Review highlighting how 3D printing/bioprinting enables architecturally defined, biomimetic scaffolds—including for skin and soft tissue regeneration—supporting more tailored wound-healing constructs.

Regenerative adjuncts · PRP

Exploration of the Therapeutic Protocols and Underlying Molecular Mechanisms of Autologous Platelet-Rich Plasma in the Treatment of Deep Second-Degree Burns

Protocol-level signal that leukocyte-poor PRP and early application may optimize burn wound healing while avoiding potential overexpression of profibrotic TGF-β seen with overly frequent treatments.

Implants · Long-term outcomes

Five-year Results of the PERLE Implant in Breast Augmentation and Augmentation-mastopexy

Multi-center series (738 patients) reporting low implant-related complication and reoperation rates through 5 years, with very low capsular contracture rates and no reported rupture, rippling, or BIA-ALCL in follow-up.

Implant surveillance · Safety measurement

Quantifying Silicone Leakage In Vivo: Validation of a Reproducible Histological Method for Breast Implant Surveillance

Validates a reproducible H&E-based capsule histology method to quantify silicone deposition (via vacuole/foam-cell imprints) and suggests a single capsule biopsy may approximate total capsule silicone burden—supporting more standardized in vivo implant surveillance.

Autologous reconstruction · Sensory restoration

Free Flap Neurotization: Indications, Techniques, and Future Directions

Summarizes sensate free-flap options and nerve coaptation strategies to restore protective sensation—an increasingly emphasized component of autologous tissue transfer in functional reconstruction.

Robotics · Facial plastic surgery

Robotics in facial plastic surgery: a systematic review and meta-analysis of the latest trends and innovations

Systematic review/meta-analysis across 14 studies finding robotic facial plastic/reconstructive procedures are feasible and span craniomaxillofacial, oculoplastic, and microsurgical indications; current tradeoffs include longer operative times and higher staffing needs, with low complication rates.

3D bioprinting · Skin/soft tissue scaffolds

The Role of 3D Printing in Regenerative Medicine: A Game-Changer in Tissue Engineering

Positions 3D printing as a platform technology for personalized scaffold fabrication (including skin constructs), enabling more controlled spatial design of regenerative wound matrices.